Modified and Ciclosporin A

Preparations of gold deposited in the synovial tissue and captured by macro-phages. Colchicine can be appoint sibylline to prevent attacks of gout. In addition, the action mesalazane reduced production interleykina1 and immunoglobulins decreases The formation of oxygen free radicals, decreases migration of neutrophils. Applied also as an antidote for poisoning by compounds of Hg, Pb. When an acute attack of gout, colchicine 12 hours after ingestion significantly reduces inflammation and pain. Another etiology of arthritis-energy colchicine shows no analgesic properties. Interleykin1 stimulates the production of collagenase, sibylline decreases collagen synthesis and proteog-face. For systemic use of prednisone, dexamethasone, triamtsino Lawn. Y those patients who spend a full course of treatment usually occurs significantly prolonged and improved. Gout uric acid crystals deposited in the synovial tissue. Macrophages and neutrophils phagocytize crystals uric acid, and secrete a glycoprotein, which causes inflammation of the joints. In connection with the side effects Dpenitsillamina sibylline 40% of patients discontinue treatment prematurely. Assign tab + yrs that release 5aminosalitsilovuyu acid only in the colon. DPenitsillamin causes nausea, mouth ulcers, alopecia, dermatitis, renal dysfunction (proteinuria), bone marrow depression (leukopenia, anemia, thrombocytopenia); possible pneumonitis and pulmonary fibrosis. Preparations of gold. In addition to rheumatoid arthritis, the drug is used in systemic lupus erythematosus and Bechterew's disease; intravenously. Significant improvement occurs within 4-5 months. Protivorevmatoidnymi properties are sulfasalazine, azathioprine, lef-lunomid and TNF antagonists - infliximab and etanercept. Inhibits tsiklooksi-genazny and 5lipoksigenazny way to becoming arachidonic acid and thus violates the synthesis of prostaglandins and leukotrienes. Glucocorticoids also have immunosuppressive properties. In acting on the body antigens activates the system of humoral immuno-niteta and produced antibodies of class E, which fixed sibylline the mast cells sibylline . These tools cause serious side effects, due to which about 1 / 3 of patients discontinue treatment prematurely. The main side-Radiation Effects: ulcerogenic action, osteoporosis, reduce resistance to infections. Glucocorticoids - High-performance anti-inflammatory drugs. To reduce the pain sibylline with acute attacks sibylline gout are also used NSAIDs (diclofenac, ibuprofen), which in this case exert nonspecific anti-inflammatory sibylline analgesic action-condition. In connection with this mesalazane not only has anti-inflammatory, and immunosuppressive properties. Glucocorticoids and NSAIDs to improve the condition of patients, but do not slow down once-vitie rheumatoid arthritis. In bronchial asthma used inhaled preparations of glucocorticoids, which are relatively little absorbed in the lungs and mainly have local anti-inflammatory effect - beclomethasone, budesonide, fluticasone, fluorescence-nizolid. NSAIDs with a systematic application even accelerate the development of rheumatoid Seriously Ill (depress product-tion of prostaglandins E and 12, which reduces the Education IL1). Cleaved in the colon under the influence of gut microflora with the release of 5aminosalitsilovoy ki-slots. Sodium aurotiomalat intramuscularly first hedgehog-day, then every week, later every month. Development of rheumatoid arthritis drugs slow down the gold Dpenitsillamin and to a lesser extent - 4aminohinoliny. Rheumatoid arthritis - an autoimmune disease, develops over of several years and leads to osteoarthritis, in which affects not only the cartilage, but bone joints. In patients with rheumatoid arthritis at regular ingestion of these drugs are beginning to have a therapeutic effect about 1 month. At the However, in their application may be nausea, headache, visual disturbances (retinopathy), sibylline dermatitis.